Evaluation of the Immunogenicity and Protective Efficacy of an Enterotoxigenic Escherichia coli CFA/I Adhesin–Heat-Labile Toxin Chimera

Recent efforts to develop an enterotoxigenic Escherichia coli (ETEC) vaccine have focused on the antigenically conserved tip adhesins of colonization factors. We showed previously that intranasal immunization with dsc(19)CfaE, a soluble variant of the in cis donor strand-complemented tip adhesin of...

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Vydáno v:Infect Immun
Hlavní autoři: O'Dowd, Aisling, Maciel, Milton, Poole, Steven T., Jobling, Michael G., Rollenhagen, Julianne E., Woods, Colleen M., Sincock, Stephanie A., McVeigh, Annette L., Gregory, Michael J., Maves, Ryan C., Prouty, Michael G., Holmes, Randall K., Savarino, Stephen J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2020
Témata:
Microbial Immunity and Vaccines
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573451/
https://ncbi.nlm.nih.gov/pubmed/32839188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00252-20
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