Effect of Zebularine in Comparison to and in Combination with Trichostatin A on CIP/KIP Family (p21Cip1/Waf1/Sdi1, p27Kip1, and p57Kip2), DNMTs (DNMT1, DNMT3a, and DNMT3b), Class I HDACs (HDACs 1, 2, 3) and Class II HDACs (HDACs 4, 5, 6) Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Colon Cancer LS 174T Cell Line

BACKGROUND: A pattern of epigenetic modifications and changes, DNA methylation and histone modification, is central to many human cancers. A variety of tumor suppressor genes (TSGs) have been demonstrated to be silenced because of histone deacetylation and DNA hypermethylation in several cancers. Re...

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Vydáno v:Asian Pac J Cancer Prev
Hlavní autoři: Sanaei, Masumeh, Kavoosi, Fraidoon
Médium: Artigo
Jazyk:Inglês
Vydáno: West Asia Organization for Cancer Prevention 2020
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573409/
https://ncbi.nlm.nih.gov/pubmed/32711442
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.31557/APJCP.2020.21.7.2131
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