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PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins
PGAP6, also known as TMEM8A, is a phospholipase A2 with specificity to glycosylphosphatidylinositol (GPI) and expressed on the surface of various cells. CRIPTO, a GPI-anchored co-receptor for a morphogenic factor Nodal, is a sensitive substrate of PGAP6. PGAP6-mediated shedding of CRIPTO plays a cri...
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| Publicado no: | J Biol Chem |
|---|---|
| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society for Biochemistry and Molecular Biology
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7573272/ https://ncbi.nlm.nih.gov/pubmed/32816994 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014643 |
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