PGAP6, a GPI-specific phospholipase A2, has narrow substrate specificity against GPI-anchored proteins

PGAP6, also known as TMEM8A, is a phospholipase A2 with specificity to glycosylphosphatidylinositol (GPI) and expressed on the surface of various cells. CRIPTO, a GPI-anchored co-receptor for a morphogenic factor Nodal, is a sensitive substrate of PGAP6. PGAP6-mediated shedding of CRIPTO plays a cri...

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Bibliografische gegevens
Gepubliceerd in:J Biol Chem
Hoofdauteurs: Lee, Gun-Hee, Fujita, Morihisa, Nakanishi, Hideki, Miyata, Haruhiko, Ikawa, Masahito, Maeda, Yusuke, Murakami, Yoshiko, Kinoshita, Taroh
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Biochemistry and Molecular Biology 2020
Onderwerpen:
Glycobiology and Extracellular Matrices
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573272/
https://ncbi.nlm.nih.gov/pubmed/32816994
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014643
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