Omega-3 Docosahexaenoic Acid (DHA) Impedes Silica-Induced Macrophage Corpse Accumulation by Attenuating Cell Death and Potentiating Efferocytosis

Airway exposure of lupus-prone NZBWF1 mice to crystalline silica (cSiO(2)), a known trigger of human autoimmune disease, elicits sterile inflammation and alveolar macrophage death in the lung that, in turn, induces early autoimmune onset and accelerates lupus progression to fatal glomerulonephritis....

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Bibliografische gegevens
Gepubliceerd in:Front Immunol
Hoofdauteurs: Rajasinghe, Lichchavi D., Chauhan, Preeti S., Wierenga, Kathryn A., Evered, Augustus O., Harris, Shamya N., Bates, Melissa A., Gavrilin, Mikhail A., Pestka, James J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Frontiers Media S.A. 2020
Onderwerpen:
Immunology
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7573148/
https://ncbi.nlm.nih.gov/pubmed/33123123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2020.02179
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