Docosahexaenoic Acid Suppresses Silica-Induced Inflammasome Activation and IL-1 Cytokine Release by Interfering With Priming Signal

Occupational exposure to respirable crystalline silica (cSiO(2)) has been etiologically linked to human autoimmunity. Intranasal instillation with cSiO(2) triggers profuse inflammation in the lung and onset of autoimmunity in lupus-prone mice; however, dietary supplementation with the omega-3 polyun...

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Udgivet i:Front Immunol
Main Authors: Wierenga, Kathryn A., Wee, Josephine, Gilley, Kristen N., Rajasinghe, Lichchavi D., Bates, Melissa A., Gavrilin, Mikhail A., Holian, Andrij, Pestka, James J.
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2019
Fag:
Immunology
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6763728/
https://ncbi.nlm.nih.gov/pubmed/31616405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02130
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