Blocking of efflux transporters in rats improves translational validation of brain radioligands

BACKGROUND: Positron emission tomography (PET) is a molecular imaging technique that can be used to investigate the in vivo pharmacology of drugs. Initial preclinical evaluation of PET tracers is often conducted in rodents due to the accessibility of disease models as well as economic considerations...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:EJNMMI Res
Prif Awduron: Shalgunov, Vladimir, Xiong, Mengfei, L’Estrade, Elina T., Raval, Nakul R., Andersen, Ida V., Edgar, Fraser G., Speth, Nikolaj R., Baerentzen, Simone L., Hansen, Hanne D., Donovan, Lene L., Nasser, Arafat, Peitersen, Siv T., Kjaer, Andreas, Knudsen, Gitte M., Syvänen, Stina, Palner, Mikael, Herth, Matthias M.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Springer Berlin Heidelberg 2020
Pynciau:
Original Research
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572968/
https://ncbi.nlm.nih.gov/pubmed/33074370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13550-020-00718-x
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