Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Triple-negative breast cancer (TNBC) and HER2-positive breast cancer are particularly aggressive and associated with unfavorable prognosis. TNBC lacks effective treatments. HER2-positive tumors have treatment options but often acquire resistance to HER2-targeted therapy after initial response. To ad...

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Gepubliceerd in:Oncogene
Hoofdauteurs: Doheny, Daniel, Sirkisoon, Sherona, Carpenter, Richard L., Aguayo, Noah Reeve, Regua, Angelina T., Anguelov, Marlyn, Manore, Sara G., Arrigo, Austin, Jalboush, Sara Abu, Wong, Grace L., Yu, Yang, Wagner, Calvin J., Chan, Michael, Ruiz, Jimmy, Thomas, Alexandra, Strowd, Roy, Lin, Jiayuh, Lo, Hui-Wen
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572897/
https://ncbi.nlm.nih.gov/pubmed/32929154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01454-1
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