Combined inhibition of JAK2-STAT3 and SMO-GLI1/tGLI1 pathways suppresses breast cancer stem cells, tumor growth, and metastasis

Triple-negative breast cancer (TNBC) and HER2-positive breast cancer are particularly aggressive and associated with unfavorable prognosis. TNBC lacks effective treatments. HER2-positive tumors have treatment options but often acquire resistance to HER2-targeted therapy after initial response. To ad...

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Bibliografiska uppgifter
I publikationen:Oncogene
Huvudupphovsmän: Doheny, Daniel, Sirkisoon, Sherona, Carpenter, Richard L., Aguayo, Noah Reeve, Regua, Angelina T., Anguelov, Marlyn, Manore, Sara G., Arrigo, Austin, Jalboush, Sara Abu, Wong, Grace L., Yu, Yang, Wagner, Calvin J., Chan, Michael, Ruiz, Jimmy, Thomas, Alexandra, Strowd, Roy, Lin, Jiayuh, Lo, Hui-Wen
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572897/
https://ncbi.nlm.nih.gov/pubmed/32929154
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-01454-1
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