Cholesterol pathway inhibition induces TGFβ signaling to promote basal differentiation in pancreatic cancer.

Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma (PDAC). Disruption of distal cholesterol biosynthesis by conditional inactivation of the ra...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:Cancer Cell
Hlavní autoři: Gabitova-Cornell, Linara, Surumbayeva, Aizhan, Peri, Suraj, Franco-Barraza, Janusz, Restifo, Diana, Weitz, Nicole, Ogier, Charline, Goldman, Aaron R., Hartman, Tiffiney R., Francescone, Ralph, Tan, Yin Fei, Nicolas, Emmanuelle, Shah, Neelima, Handorf, Elizabeth A., Cai, Kathy Q., O’Reilly, Alana M., Sloma, Ido, Chiaverelli, Rachel, Moffitt, Richard A., Khazak, Vladimir, Fang, Carolyn Y., Golemis, Erica A., Cukierman, Edna, Astsaturov, Igor
Médium: Artigo
Jazyk:Inglês
Vydáno: 2020
Témata:
Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572882/
https://ncbi.nlm.nih.gov/pubmed/32976774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.08.015
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo otaguje tento záznam!

Podobné jednotky