Cholesterol pathway inhibition induces TGFβ signaling to promote basal differentiation in pancreatic cancer.

Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma (PDAC). Disruption of distal cholesterol biosynthesis by conditional inactivation of the ra...

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Detaylı Bibliyografya
Yayımlandı:Cancer Cell
Asıl Yazarlar: Gabitova-Cornell, Linara, Surumbayeva, Aizhan, Peri, Suraj, Franco-Barraza, Janusz, Restifo, Diana, Weitz, Nicole, Ogier, Charline, Goldman, Aaron R., Hartman, Tiffiney R., Francescone, Ralph, Tan, Yin Fei, Nicolas, Emmanuelle, Shah, Neelima, Handorf, Elizabeth A., Cai, Kathy Q., O’Reilly, Alana M., Sloma, Ido, Chiaverelli, Rachel, Moffitt, Richard A., Khazak, Vladimir, Fang, Carolyn Y., Golemis, Erica A., Cukierman, Edna, Astsaturov, Igor
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572882/
https://ncbi.nlm.nih.gov/pubmed/32976774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.08.015
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