Cholesterol pathway inhibition induces TGFβ signaling to promote basal differentiation in pancreatic cancer.

Oncogenic transformation alters lipid metabolism to sustain tumor growth. We define a mechanism by which cholesterol metabolism controls the development and differentiation of pancreatic ductal adenocarcinoma (PDAC). Disruption of distal cholesterol biosynthesis by conditional inactivation of the ra...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Gabitova-Cornell, Linara, Surumbayeva, Aizhan, Peri, Suraj, Franco-Barraza, Janusz, Restifo, Diana, Weitz, Nicole, Ogier, Charline, Goldman, Aaron R., Hartman, Tiffiney R., Francescone, Ralph, Tan, Yin Fei, Nicolas, Emmanuelle, Shah, Neelima, Handorf, Elizabeth A., Cai, Kathy Q., O’Reilly, Alana M., Sloma, Ido, Chiaverelli, Rachel, Moffitt, Richard A., Khazak, Vladimir, Fang, Carolyn Y., Golemis, Erica A., Cukierman, Edna, Astsaturov, Igor
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2020
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572882/
https://ncbi.nlm.nih.gov/pubmed/32976774
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2020.08.015
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