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Up-regulation of the p75 neurotrophin receptor is an essential mechanism for HIV-gp120 mediated synaptic loss in the striatum

Reduced synaptodendritic complexity appears to be a key feature in human immunodeficiency virus (HIV)-associated neurological disorder (HAND). Viral proteins, and in particular the envelope protein gp120, play a role in the pathology of synapses. Gp120 has been shown to increase both in vitro and in...

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Publicado en:Brain Behav Immun
Main Authors: Speidell, Andrew, Asuni, Gino Paolo, Wakulski, Renee, Mocchetti, Italo
Formato: Artigo
Idioma:Inglês
Publicado: 2020
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7572812/
https://ncbi.nlm.nih.gov/pubmed/32717404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbi.2020.07.023
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