Design of a small molecule that stimulates vascular endothelial growth factor A enabled by screening RNA fold–small molecule interactions

Vascular endothelial growth factor A (VEGFA) stimulates angiogenesis in human endothelial cells, and increasing its expression is a potential treatment for heart failure. Here, we report the design of a small molecule (TGP-377) that specifically and potently enhances VEGFA expression by the targetin...

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Detalhes bibliográficos
Publicado no:Nat Chem
Main Authors: Haniff, Hafeez S., Knerr, Laurent, Liu, Xiaohui, Crynen, Gogce, Boström, Jonas, Abegg, Daniel, Adibekian, Alexander, Lekah, Elizabeth, Wang, Kye Won, Cameron, Michael D., Yildirim, Ilyas, Lemurell, Malin, Disney, Matthew D.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7571259/
https://ncbi.nlm.nih.gov/pubmed/32839603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41557-020-0514-4
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