Mechanistic analysis of A46V, H57Y, and D129N in pyrazinamidase associated with pyrazinamide resistance

Pyrazinamide (PZA) is a component of first-line drugs, active against latent Mycobacterium tuberculosis (MTB) isolates. The prodrug is activated into the active form, pyrazinoic acid (POA) via pncA gene-encoded pyrazinamidase (PZase). Mutations in pncA have been reported, most commonly responsible f...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Saudi J Biol Sci
Päätekijät: Khan, Muhammad Tahir, Chinnasamy, Sathishkumar, Cui, Zhilei, Irfan, Muhammad, Wei, Dong-Qing
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Elsevier 2020
Aiheet:
Original Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7569123/
https://ncbi.nlm.nih.gov/pubmed/33100877
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.sjbs.2020.07.015
Tagit: Lisää tagi
Ei tageja, Lisää ensimmäinen tagi!

Samankaltaisia teoksia