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Subunit-selective iGluR antagonists can potentiate heteromeric receptor responses by blocking desensitization

Ionotropic glutamate receptors (iGluRs) are key molecules for synaptic signaling in the central nervous system, which makes them promising drug targets. Intensive efforts are being devoted to the development of subunit-selective ligands, which should enable more precise pharmacologic interventions w...

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Bibliografiske detaljer
Udgivet i:Proc Natl Acad Sci U S A
Main Authors: Pollok, Stefan, Reiner, Andreas
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2020
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7568280/
https://ncbi.nlm.nih.gov/pubmed/32999066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2007471117
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