Structural and functional analysis of protective antibodies targeting the threefold plateau of enterovirus 71

Enterovirus 71 (EV71)-neutralizing antibodies correlate with protection and have potential as therapeutic agents. We isolate and characterize a panel of plasmablast-derived monoclonal antibodies from an infected child whose antibody response focuses on the plateau epitope near the icosahedral 3-fold...

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Vydáno v:Nat Commun
Hlavní autoři: Huang, Kuan-Ying A., Zhou, Daming, Fry, Elizabeth E., Kotecha, Abhay, Huang, Peng-Nien, Yang, Shu-Li, Tsao, Kuo-Chien, Huang, Yhu-Chering, Lin, Tzou-Yien, Ren, Jingshan, Stuart, David I.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567869/
https://ncbi.nlm.nih.gov/pubmed/33067459
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19013-3
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