Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti–COVID-19 drug design

Viral papain-like cysteine protease (PLpro, NSP3) is essential for SARS-CoV-2 replication and represents a promising target for the development of antiviral drugs. Here, we used a combinatorial substrate library and performed comprehensive activity profiling of SARS-CoV-2 PLpro. On the scaffold of t...

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Detalles Bibliográficos
Publicado en:Sci Adv
Main Authors: Rut, Wioletta, Lv, Zongyang, Zmudzinski, Mikolaj, Patchett, Stephanie, Nayak, Digant, Snipas, Scott J., El Oualid, Farid, Huang, Tony T., Bekes, Miklos, Drag, Marcin, Olsen, Shaun K.
Formato: Artigo
Idioma:Inglês
Publicado: American Association for the Advancement of Science 2020
Assuntos:
Research Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567588/
https://ncbi.nlm.nih.gov/pubmed/33067239
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.abd4596
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