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Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes

Deubiquitinating enzymes (DUBs) are responsible for removing ubiquitin (Ub) from its protein conjugates. DUBs have been implicated as attractive therapeutic targets in the treatment of viral diseases, neurodegenerative disorders and cancer. The lack of selective chemical tools for the exploration of...

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Detalhes bibliográficos
Publicado no:Chem Sci
Main Authors: Rut, Wioletta, Zmudzinski, Mikolaj, Snipas, Scott J., Bekes, Miklos, Huang, Tony T., Drag, Marcin
Formato: Artigo
Idioma:Inglês
Publicado em: Royal Society of Chemistry 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7477763/
https://ncbi.nlm.nih.gov/pubmed/32953009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/d0sc01347a
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