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Positional-scanning fluorogenic substrate libraries reveal unexpected specificity determinants of deubiquitinating enzymes (DUBs)

Deubiquitinating enzymes (DUBs) are a family of proteases responsible for the specific removal of ubiquitin attached to target proteins and thus control the free cellular pools of this molecule. DUB activity is usually assayed using full-length ubiquitin, and these enzymes generally show low activit...

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Bibliografische gegevens
Hoofdauteurs: Drag, Marcin, Mikolajczyk, Jowita, Bekes, Miklos, Reyes-Turcu, Francisca E., Ellman, Jonathan A., Wilkinson, Keith D., Salvesen, Guy S.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2008
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Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766241/
https://ncbi.nlm.nih.gov/pubmed/18601651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080779
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