Positional-scanning fluorogenic substrate libraries reveal unexpected specificity determinants of deubiquitinating enzymes (DUBs)

Deubiquitinating enzymes (DUBs) are a family of proteases responsible for the specific removal of ubiquitin attached to target proteins and thus control the free cellular pools of this molecule. DUB activity is usually assayed using full-length ubiquitin, and these enzymes generally show low activit...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Drag, Marcin, Mikolajczyk, Jowita, Bekes, Miklos, Reyes-Turcu, Francisca E., Ellman, Jonathan A., Wilkinson, Keith D., Salvesen, Guy S.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2008
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC2766241/
https://ncbi.nlm.nih.gov/pubmed/18601651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20080779
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