Novel tacrine–benzofuran hybrids as potential multi-target drug candidates for the treatment of Alzheimer’s Disease

Pursuing the widespread interest on multi-target drugs to combat Alzheimer´s disease (AD), a new series of hybrids was designed and developed based on the repositioning of the well-known acetylcholinesterase (AChE) inhibitor, tacrine (TAC), by its coupling to benzofuran (BF) derivatives. The BF fram...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Fancellu, Gaia, Chand, Karam, Tomás, Daniel, Orlandini, Elisabetta, Piemontese, Luca, Silva, Diana F., Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2019
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567501/
https://ncbi.nlm.nih.gov/pubmed/31760822
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1689237
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