Donepezil structure-based hybrids as potential multifunctional anti-Alzheimer’s drug candidates

A new series of multifunctional hybrids, based on the structure of the donepezil (DNP) drug, have been developed and evaluated as potential anti Alzheimer’s disease (AD) agents. The rationale of this study was the conjugation of a benzylpiperidine/benzylpiperazine moiety with derivatives of bioactiv...

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Detalhes bibliográficos
Publicado no:J Enzyme Inhib Med Chem
Main Authors: Piemontese, Luca, Tomás, Daniel, Hiremathad, Asha, Capriati, Vito, Candeias, Emanuel, Cardoso, Sandra M., Chaves, Sílvia, Santos, M. Amélia
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2018
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6127844/
https://ncbi.nlm.nih.gov/pubmed/30160188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2018.1491564
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