Determination of the melanocortin-4 receptor structure identifies Ca(2+) as a cofactor for ligand binding

The melanocortin-4 receptor (MC4R) is involved in energy homeostasis and is an important drug target for syndromic obesity. We report the structure of the antagonist SHU9119-bound human MC4R at 2.8-angstrom resolution. Ca(2+) is identified as a cofactor that is complexed with residues from both the...

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Publicat a:Science
Autors principals: Yu, Jing, Gimenez, Luis E., Hernandez, Ciria C., Wu, Yiran, Wein, Ariel H., Han, Gye Won, McClary, Kyle, Mittal, Sanraj R., Burdsall, Kylie, Stauch, Benjamin, Wu, Lijie, Stevens, Sophia N., Peisley, Alys, Williams, Savannah Y., Chen, Valerie, Millhauser, Glenn L., Zhao, Suwen, Cone, Roger D., Stevens, Raymond C.
Format: Artigo
Idioma:Inglês
Publicat: 2020
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567314/
https://ncbi.nlm.nih.gov/pubmed/32327598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaz8995
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