Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing

Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from a liver associated with biliary atresia. Hepato...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Nishiwaki, Manami, Toyoda, Masashi, Oishi, Yoshie, Ishida, Seiichi, Horiuchi, Shin-ichiro, Makino-Itou, Hatsune, Kimura, Tohru, Ohno, Shin-ichi, Ohkura, Takashi, Enosawa, Shin, Akutsu, Hidenori, Nakazawa, Atsuko, Kasahara, Mureo, Kiyono, Tohru, Umezawa, Akihiro
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567112/
https://ncbi.nlm.nih.gov/pubmed/33060611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73992-3
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