Immortalization of human hepatocytes from biliary atresia with CDK4(R24C), cyclin D1, and TERT for cytochrome P450 induction testing

Hepatocytes are an important tool for in vitro toxicology testing. In addition to primary cultures, a limited number of immortalized cell lines have been developed. We here describe a new cell line, designated as HepaMN, which has been established from a liver associated with biliary atresia. Hepato...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Sci Rep
Egile Nagusiak: Nishiwaki, Manami, Toyoda, Masashi, Oishi, Yoshie, Ishida, Seiichi, Horiuchi, Shin-ichiro, Makino-Itou, Hatsune, Kimura, Tohru, Ohno, Shin-ichi, Ohkura, Takashi, Enosawa, Shin, Akutsu, Hidenori, Nakazawa, Atsuko, Kasahara, Mureo, Kiyono, Tohru, Umezawa, Akihiro
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2020
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567112/
https://ncbi.nlm.nih.gov/pubmed/33060611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-73992-3
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