The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

SETDB1, a histone H3 lysine 9 (H3K9) methyltransferase, is crucial in meiosis and embryo development. This study aimed to investigate whether SETDB1 was associated with spermatogonial stem cells (SSC) homeostasis. We found that knockdown of Setdb1 impaired cell proliferation, led to an increase in r...

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Detalhes bibliográficos
Publicado no:Front Genet
Main Authors: Li, Xueliang, Chen, Xiaoxu, Liu, Yingdong, Zhang, Pengfei, Zheng, Yi, Zeng, Wenxian
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567028/
https://ncbi.nlm.nih.gov/pubmed/33133132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00997
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