The Histone Methyltransferase SETDB1 Modulates Survival of Spermatogonial Stem/Progenitor Cells Through NADPH Oxidase

SETDB1, a histone H3 lysine 9 (H3K9) methyltransferase, is crucial in meiosis and embryo development. This study aimed to investigate whether SETDB1 was associated with spermatogonial stem cells (SSC) homeostasis. We found that knockdown of Setdb1 impaired cell proliferation, led to an increase in r...

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Bibliografiske detaljer
Udgivet i:Front Genet
Main Authors: Li, Xueliang, Chen, Xiaoxu, Liu, Yingdong, Zhang, Pengfei, Zheng, Yi, Zeng, Wenxian
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2020
Fag:
Genetics
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7567028/
https://ncbi.nlm.nih.gov/pubmed/33133132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2020.00997
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