The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma

The most common mutation in melanoma, BRAF(V600E), activates the BRAF serine/threonine kinase and causes excessive MAPK pathway activity(1,2). BRAF(V600E)mutations are also present in benign melanocytic nevi(3), highlighting the importance of additional genetic alterations in the genesis of malignan...

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Detalhes bibliográficos
Main Authors: Ceol, Craig J., Houvras, Yariv, Jane-Valbuena, Judit, Bilodeau, Steve, Orlando, David A., Battisti, Valentine, Fritsch, Lauriane, Lin, William M., Hollmann, Travis J., Ferré, Fabrizio, Bourque, Caitlin, Burke, Christopher J., Turner, Laura, Uong, Audrey, Johnson, Laura A., Beroukhim, Rameen, Mermel, Craig H., Loda, Massimo, Ait-Si-Ali, Slimane, Garraway, Levi A., Young, Richard A., Zon, Leonard I.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348545/
https://ncbi.nlm.nih.gov/pubmed/21430779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09806
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