The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma

The most common mutation in melanoma, BRAF(V600E), activates the BRAF serine/threonine kinase and causes excessive MAPK pathway activity(1,2). BRAF(V600E)mutations are also present in benign melanocytic nevi(3), highlighting the importance of additional genetic alterations in the genesis of malignan...

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Autori principali: Ceol, Craig J., Houvras, Yariv, Jane-Valbuena, Judit, Bilodeau, Steve, Orlando, David A., Battisti, Valentine, Fritsch, Lauriane, Lin, William M., Hollmann, Travis J., Ferré, Fabrizio, Bourque, Caitlin, Burke, Christopher J., Turner, Laura, Uong, Audrey, Johnson, Laura A., Beroukhim, Rameen, Mermel, Craig H., Loda, Massimo, Ait-Si-Ali, Slimane, Garraway, Levi A., Young, Richard A., Zon, Leonard I.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348545/
https://ncbi.nlm.nih.gov/pubmed/21430779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09806
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