The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma

The most common mutation in melanoma, BRAF(V600E), activates the BRAF serine/threonine kinase and causes excessive MAPK pathway activity(1,2). BRAF(V600E)mutations are also present in benign melanocytic nevi(3), highlighting the importance of additional genetic alterations in the genesis of malignan...

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Detaylı Bibliyografya
Asıl Yazarlar: Ceol, Craig J., Houvras, Yariv, Jane-Valbuena, Judit, Bilodeau, Steve, Orlando, David A., Battisti, Valentine, Fritsch, Lauriane, Lin, William M., Hollmann, Travis J., Ferré, Fabrizio, Bourque, Caitlin, Burke, Christopher J., Turner, Laura, Uong, Audrey, Johnson, Laura A., Beroukhim, Rameen, Mermel, Craig H., Loda, Massimo, Ait-Si-Ali, Slimane, Garraway, Levi A., Young, Richard A., Zon, Leonard I.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3348545/
https://ncbi.nlm.nih.gov/pubmed/21430779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature09806
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