Discovery of orally available spirodiketopiperazine-based CCR5 antagonists

Using the previously reported novel spirodiketopiperazine scaffold, the design and synthesis of orally available CCR5 antagonists was undertaken. Compounds possessing 3 carboxylic acid function in the appropriate position showed improved oral exposure (AUC) relative to the initial chemical leads wit...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Bioorg Med Chem
Prif Awduron: Nishizawa, Rena, Nishiyama, Toshihiko, Hisaichi, Katsuya, Hirai, Keisuke, Habashita, Hiromu, Takaoka, Yoshikazu, Tada, Hideaki, Sagawa, Kenji, Shibayama, Shiro, Maeda, Kenji, Mitsuya, Hiroaki, Nakai, Hisao, Fukushima, Daikichi, Toda, Masaaki
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2010
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566811/
https://ncbi.nlm.nih.gov/pubmed/20542438
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.05.057
Tagiau: Ychwanegu Tag
Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!

Eitemau Tebyg