Multiplex melanoma families are enriched for polygenic risk

Cancers, including cutaneous melanoma, can cluster in families. In addition to environmental etiological factors such as ultraviolet radiation, cutaneous melanoma has a strong genetic component. Genetic risks for cutaneous melanoma range from rare, high-penetrance mutations to common, low-penetrance...

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Enregistré dans:
Détails bibliographiques
Publié dans:Hum Mol Genet
Auteurs principaux: Law, Matthew H, Aoude, Lauren G, Duffy, David L, Long, Georgina V, Johansson, Peter A, Pritchard, Antonia L, Khosrotehrani, Kiarash, Mann, Graham J, Montgomery, Grant W, Iles, Mark M, Cust, Anne E, Palmer, Jane M, Shannon, Kerwin F, Spillane, Andrew J, Stretch, Jonathan R, Thompson, John F, Saw, Robyn P M, Scolyer, Richard A, Martin, Nicholas G, Hayward, Nicholas K, MacGregor, Stuart
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2020
Sujets:
Association Studies Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566496/
https://ncbi.nlm.nih.gov/pubmed/32716505
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddaa156
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