A Rapid Caspase-11 Response Induced by IFNγ Priming Is Independent of Guanylate Binding Proteins

In mammalian cells, inflammatory caspases detect Gram-negative bacterial invasion by binding lipopolysaccharides (LPS). Murine caspase-11 binds cytosolic LPS, stimulates pyroptotic cell death, and drives sepsis pathogenesis. Extracellular priming factors enhance caspase-11-dependent pyroptosis. Here...

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Udgivet i:iScience
Main Authors: Brubaker, Sky W., Brewer, Susan M., Massis, Liliana M., Napier, Brooke A., Monack, Denise M.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566093/
https://ncbi.nlm.nih.gov/pubmed/33089101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101612
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