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A Rapid Caspase-11 Response Induced by IFNγ Priming Is Independent of Guanylate Binding Proteins
In mammalian cells, inflammatory caspases detect Gram-negative bacterial invasion by binding lipopolysaccharides (LPS). Murine caspase-11 binds cytosolic LPS, stimulates pyroptotic cell death, and drives sepsis pathogenesis. Extracellular priming factors enhance caspase-11-dependent pyroptosis. Here...
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| Publicado no: | iScience |
|---|---|
| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2020
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7566093/ https://ncbi.nlm.nih.gov/pubmed/33089101 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2020.101612 |
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