miR-18a Contributes to Preeclampsia by Downregulating Smad2 (Full Length) and Reducing TGF-β Signaling

The study investigated the regulation of Smad2 by miR-18a and its role in preeclampsia (PE). Bioinformatics analysis showed that both Smad2 and Smad3 were the predicted targets for miR-18a. Mass spectrum analysis showed that two mature Smad2 isoforms existed in human placenta: full length, Smad2(FL)...

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Detalhes bibliográficos
Publicado no:Mol Ther Nucleic Acids
Main Authors: Xu, Peng, Li, Zhilang, Wang, Yongqing, Yu, Xin, Shao, Xuan, Li, Yu-xia, Peng, Chun, Zhao, Yangyu, Wang, Yan-Ling
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Gene & Cell Therapy 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7566009/
https://ncbi.nlm.nih.gov/pubmed/33230456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.omtn.2020.09.019
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