Antigenicity and Immunogenicity of HIV-1 Envelope Trimers Complexed to a Small-Molecule Viral Entry Inhibitor

Small-molecule viral entry inhibitors, such as BMS-626529 (BMS-529), allosterically block CD4 binding to HIV-1 envelope (Env) and inhibit CD4-induced structural changes in Env trimers. Here, we show that the binding of BMS-529 to clade C soluble chimeric gp140 SOSIP (ch.SOSIP) and membrane-bound tri...

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Detaylı Bibliyografya
Yayımlandı:J Virol
Asıl Yazarlar: Alam, S. Munir, Cronin, Kenneth, Parks, Robert, Anasti, Kara, Ding, Haitao, Go, Eden P., Desaire, Heather, Eaton, Amanda, Montefiori, David, Sodroski, Joseph, Kappes, John, Haynes, Barton F., Saunders, Kevin O.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Society for Microbiology 2020
Konular:
Vaccines and Antiviral Agents
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565611/
https://ncbi.nlm.nih.gov/pubmed/32817216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00958-20
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