Antigenicity and Immunogenicity of HIV-1 Envelope Trimers Complexed to a Small-Molecule Viral Entry Inhibitor

Small-molecule viral entry inhibitors, such as BMS-626529 (BMS-529), allosterically block CD4 binding to HIV-1 envelope (Env) and inhibit CD4-induced structural changes in Env trimers. Here, we show that the binding of BMS-529 to clade C soluble chimeric gp140 SOSIP (ch.SOSIP) and membrane-bound tri...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Alam, S. Munir, Cronin, Kenneth, Parks, Robert, Anasti, Kara, Ding, Haitao, Go, Eden P., Desaire, Heather, Eaton, Amanda, Montefiori, David, Sodroski, Joseph, Kappes, John, Haynes, Barton F., Saunders, Kevin O.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2020
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565611/
https://ncbi.nlm.nih.gov/pubmed/32817216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00958-20
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados