BMS-599626, a Highly Selective Pan-HER Kinase Inhibitor, Antagonizes ABCG2-Mediated Drug Resistance

SIMPLE SUMMARY: ABC transporters comprise a large group of ATP binding plasma membrane proteins, classified into subfamilies A-G, that transport substrates out of cells to maintain homeostasis. Prolonged exposure to chemotherapeutic drugs leads to increased expression of ABC transporters in cancer c...

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Vydáno v:Cancers (Basel)
Hlavní autoři: Ashar, Yunali V., Zhou, Jingchun, Gupta, Pranav, Teng, Qiu-Xu, Lei, Zi-Ning, Reznik, Sandra E., Lusvarghi, Sabrina, Wurpel, John, Ambudkar, Suresh V., Chen, Zhe-Sheng
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7565406/
https://ncbi.nlm.nih.gov/pubmed/32899268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092502
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