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Genetically encoded protein sulfation in mammalian cells

Tyrosine sulfation is an important post-translational modification found in higher eukaryotes. Here we report an engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells. This platform enables recombina...

詳細記述

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書誌詳細
出版年:Nat Chem Biol
主要な著者: Italia, James S., Peeler, Jennifer C., Hillenbrand, Christen M., Latour, Christopher, Weerapana, Eranthie, Chatterjee, Abhishek
フォーマット: Artigo
言語:Inglês
出版事項: 2020
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564891/
https://ncbi.nlm.nih.gov/pubmed/32198493
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0493-1
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