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Genetically encoded protein sulfation in mammalian cells
Tyrosine sulfation is an important post-translational modification found in higher eukaryotes. Here we report an engineered tyrosyl-tRNA synthetase/tRNA pair that co-translationally incorporates O-sulfotyrosine in response to UAG codons in E. coli and mammalian cells. This platform enables recombina...
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| Foilsithe in: | Nat Chem Biol |
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| Main Authors: | , , , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
2020
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7564891/ https://ncbi.nlm.nih.gov/pubmed/32198493 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-020-0493-1 |
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