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Mutually orthogonal nonsense-suppression systems and conjugation chemistries for precise protein labeling at up to three distinct sites

Site-specific incorporation of multiple distinct noncanonical amino acids (ncAAs) into a protein is an emerging technology with tremendous potential, which relies on mutually orthogonal engineered aminoacyl-tRNA synthetase/tRNA pairs that suppress different nonsense/frameshift codons. So far, up to...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Am Chem Soc
Prif Awduron: Italia, James S., Addy, Partha Sarathi, Erickson, Sarah B., Peeler, Jennifer C., Weerapana, Eranthie, Chatterjee, Abhishek
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500092/
https://ncbi.nlm.nih.gov/pubmed/30909694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jacs.8b12954
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