Loss of Two-Pore Channel 2 (TPC2) Expression Increases the Metastatic Traits of Melanoma Cells by a Mechanism Involving the Hippo Signalling Pathway and Store-Operated Calcium Entry

Melanoma is one of the most aggressive and treatment-resistant human cancers. The two-pore channel 2 (TPC2) is located on late endosomes, lysosomes and melanosomes. Here, we characterized how TPC2 knockout (KO) affected human melanoma cells derived from a metastatic site. TPC2 KO increased these cel...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: D’Amore, Antonella, Hanbashi, Ali Ahmed, Di Agostino, Silvia, Palombi, Fioretta, Sacconi, Andrea, Voruganti, Aniruddha, Taggi, Marilena, Canipari, Rita, Blandino, Giovanni, Parrington, John, Filippini, Antonio
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564716/
https://ncbi.nlm.nih.gov/pubmed/32846966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers12092391
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