Adjuvantation of an Influenza Hemagglutinin Antigen with TLR4 and NOD2 Agonists Encapsulated in Poly(D,L-Lactide-Co-Glycolide) Nanoparticles Enhances Immunogenicity and Protection against Lethal Influenza Virus Infection in Mice

Along with their excellent safety profiles, subunit vaccines are typically characterized by much weaker immunogenicity and protection efficacy compared to whole-pathogen vaccines. Here, we present an approach aimed at bridging this disadvantage that is based on synergistic collaboration between patt...

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Vydáno v:Vaccines (Basel)
Hlavní autoři: Tukhvatulin, Amir, Dzharullaeva, Alina, Erokhova, Alina, Zemskaya, Anastasia, Balyasin, Maxim, Ozharovskaia, Tatiana, Zubkova, Olga, Shevlyagina, Natalia, Zhukhovitsky, Vladimir, Fedyakina, Irina, Pruss, Ivan, Shcheblyakov, Dmitry, Naroditsky, Boris, Logunov, Denis, Gintsburg, Alexander
Médium: Artigo
Jazyk:Inglês
Vydáno: MDPI 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564367/
https://ncbi.nlm.nih.gov/pubmed/32927915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/vaccines8030519
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