Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses

Binding of pattern recognition receptors (PRRs) by pathogen-associated molecular patterns (PAMPs) activates innate immune responses and contributes to development of adaptive immunity. Simultaneous stimulation of different types of PRRs can have synergistic immunostimulatory effects resulting in enh...

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Veröffentlicht in:PLoS One
Hauptverfasser: Tukhvatulin, Amir I., Dzharullaeva, Alina S., Tukhvatulina, Natalia M., Shcheblyakov, Dmitry V., Shmarov, Maxim M., Dolzhikova, Inna V., Stanhope-Baker, Patricia, Naroditsky, Boris S., Gudkov, Andrei V., Logunov, Denis Y., Gintsburg, Alexander L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871337/
https://ncbi.nlm.nih.gov/pubmed/27187797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155650
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