Powerful Complex Immunoadjuvant Based on Synergistic Effect of Combined TLR4 and NOD2 Activation Significantly Enhances Magnitude of Humoral and Cellular Adaptive Immune Responses

Binding of pattern recognition receptors (PRRs) by pathogen-associated molecular patterns (PAMPs) activates innate immune responses and contributes to development of adaptive immunity. Simultaneous stimulation of different types of PRRs can have synergistic immunostimulatory effects resulting in enh...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Tukhvatulin, Amir I., Dzharullaeva, Alina S., Tukhvatulina, Natalia M., Shcheblyakov, Dmitry V., Shmarov, Maxim M., Dolzhikova, Inna V., Stanhope-Baker, Patricia, Naroditsky, Boris S., Gudkov, Andrei V., Logunov, Denis Y., Gintsburg, Alexander L.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871337/
https://ncbi.nlm.nih.gov/pubmed/27187797
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0155650
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