Icariside Ⅱ, a main compound in Epimedii Folium, induces idiosyncratic hepatotoxicity by enhancing NLRP3 inflammasome activation

Idiosyncratic drug-induced liver injury (IDILI) is an infrequent but potentially serious disease that develops the main reason for post-marketing safety warnings and withdrawals of drugs. Epimedii Folium (EF), the widely used herbal medicine, has shown to cause idiosyncratic liver injury, but the un...

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Bibliografiske detaljer
Udgivet i:Acta Pharm Sin B
Main Authors: Wang, Zhilei, Xu, Guang, Wang, Hongbo, Zhan, Xiaoyan, Gao, Yuan, Chen, Nian, Li, Ruisheng, Song, Xueai, Guo, Yuming, Yang, Ruichuang, Niu, Ming, Wang, Jiabo, Liu, Youping, Xiao, Xiaohe, Bai, Zhaofang
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2020
Fag:
Original Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7564030/
https://ncbi.nlm.nih.gov/pubmed/33088683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.03.006
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