First small-molecule PROTACs for G protein-coupled receptors: inducing α(1A)-adrenergic receptor degradation

Proteolysis targeting chimeras (PROTACs) are dual-functional hybrid molecules that can selectively recruit an E3 ubiquitin ligase to a target protein to direct the protein into the ubiquitin-proteasome system (UPS), thereby selectively reducing the target protein level by the ubiquitin-proteasome pa...

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Detalhes bibliográficos
Publicado no:Acta Pharm Sin B
Main Authors: Li, Zhenzhen, Lin, Yuxing, Song, Hui, Qin, Xiaojun, Yu, Zhongxia, Zhang, Zheng, Dong, Gaopan, Li, Xiang, Shi, Xiaodong, Du, Lupei, Zhao, Wei, Li, Minyong
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2020
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7563999/
https://ncbi.nlm.nih.gov/pubmed/33088687
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.apsb.2020.01.014
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