DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

During neuronal differentiation, the transcriptional profile and the epigenetic context of neural committed cells is subject to significant rearrangements, but a systematic quantification of global histone modification changes is still missing. Here, we show that H3K79me2 increases and H3K27ac decre...

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Detaylı Bibliyografya
Yayımlandı:Nat Commun
Asıl Yazarlar: Ferrari, Francesco, Arrigoni, Laura, Franz, Henriette, Izzo, Annalisa, Butenko, Ludmila, Trompouki, Eirini, Vogel, Tanja, Manke, Thomas
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Nature Publishing Group UK 2020
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC7562744/
https://ncbi.nlm.nih.gov/pubmed/33060580
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-19001-7
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