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Differential Methylation of H3K79 Reveals DOT1L Target Genes and Function in the Cerebellum In Vivo
The disruptor of telomeric silencing 1-like (DOT1L) mediates methylation of histone H3 at position lysine 79 (H3K79). Conditional knockout of Dot1l in mouse cerebellar granule cells (Dot1l-cKO(Atoh1)) led to a smaller external granular layer with fewer precursors of granule neurons. Dot1l-cKO(Atoh1)...
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| Publicado no: | Mol Neurobiol |
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| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Springer US
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6505521/ https://ncbi.nlm.nih.gov/pubmed/30302725 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1377-1 |
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