ERK1/2 phosphorylation of FHOD connects signaling and nuclear positioning alternations in cardiac laminopathy

Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate ERK1/2 activity in heart and its inhibition ameliorates pathology, but the downstream effectors remain largely unknown. We now show that card...

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Gepubliceerd in:Dev Cell
Hoofdauteurs: Antoku, Susumu, Wu, Wei, Joseph, Leroy C., Morrow, John P., Worman, Howard J., Gundersen, Gregg G.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7561008/
https://ncbi.nlm.nih.gov/pubmed/31794718
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.10.023
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