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ERK1/2 phosphorylation of FHOD connects signaling and nuclear positioning alternations in cardiac laminopathy
Mutations in the lamin A/C gene (LMNA) cause cardiomyopathy and also disrupt nuclear positioning in fibroblasts. LMNA mutations causing cardiomyopathy elevate ERK1/2 activity in heart and its inhibition ameliorates pathology, but the downstream effectors remain largely unknown. We now show that card...
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| Publicado no: | Dev Cell |
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| Main Authors: | , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7561008/ https://ncbi.nlm.nih.gov/pubmed/31794718 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2019.10.023 |
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