Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer

Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled-Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives...

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Pubblicato in:Int J Cancer
Autori principali: Perry, Antoinette S., O’Hurley, Gillian, Raheem, Omer A., Brennan, Kevin, Wong, Simon, O’Grady, Anthony, Kennedy, Anne-Marie, Marignol, Laure, Murphy, Therese M., Sullivan, Linda, Barrett, Ciara, Loftus, Barbara, Thornhill, John, Hewitt, Stephen M., Lawler, Mark, Kay, Elaine, Lynch, Thomas, Hollywood, Donal
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560947/
https://ncbi.nlm.nih.gov/pubmed/22915211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27798
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