Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer

Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled-Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives...

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Bibliographic Details
Published in:Int J Cancer
Main Authors: Perry, Antoinette S., O’Hurley, Gillian, Raheem, Omer A., Brennan, Kevin, Wong, Simon, O’Grady, Anthony, Kennedy, Anne-Marie, Marignol, Laure, Murphy, Therese M., Sullivan, Linda, Barrett, Ciara, Loftus, Barbara, Thornhill, John, Hewitt, Stephen M., Lawler, Mark, Kay, Elaine, Lynch, Thomas, Hollywood, Donal
Format: Artigo
Language:Inglês
Published: 2012
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560947/
https://ncbi.nlm.nih.gov/pubmed/22915211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27798
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