Gene expression and epigenetic discovery screen reveal methylation of SFRP2 in prostate cancer

Aberrant activation of Wnts is common in human cancers, including prostate. Hypermethylation associated transcriptional silencing of Wnt antagonist genes SFRPs (Secreted Frizzled-Related Proteins) is a frequent oncogenic event. The significance of this is not known in prostate cancer. The objectives...

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Bibliografiska uppgifter
I publikationen:Int J Cancer
Huvudupphovsmän: Perry, Antoinette S., O’Hurley, Gillian, Raheem, Omer A., Brennan, Kevin, Wong, Simon, O’Grady, Anthony, Kennedy, Anne-Marie, Marignol, Laure, Murphy, Therese M., Sullivan, Linda, Barrett, Ciara, Loftus, Barbara, Thornhill, John, Hewitt, Stephen M., Lawler, Mark, Kay, Elaine, Lynch, Thomas, Hollywood, Donal
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2012
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7560947/
https://ncbi.nlm.nih.gov/pubmed/22915211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ijc.27798
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